Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation-Reference-Cited by-同舟云学术

Graft-derived extracellular vesicles transported across subcapsular sinus macrophages elicit B cell alloimmunity after transplantation

Published:2021-03-17 Issue:585 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zeng Furong¹²³^ORCID,Chen Zhizhao¹³⁴^ORCID,Chen Rao¹⁵^ORCID,Shufesky William J.¹,Bandyopadhyay Mohna⁶^ORCID,Camirand Geoffrey¹⁷^ORCID,Oberbarnscheidt Martin H.¹⁷^ORCID,Sullivan Mara L. G.⁸^ORCID,Baty Catherine J.⁹^ORCID,Yang Mu-qing¹^ORCID,Calderon Michel⁸^ORCID,Stolz Donna Beer⁸^ORCID,Erdos Geza⁶^ORCID,Pelanda Roberta¹⁰^ORCID,Brennan Todd V.¹¹^ORCID,Catz Sergio D.¹²^ORCID,Watkins Simon C.⁸^ORCID,Larregina Adriana T.⁶⁷¹³^ORCID,Morelli Adrian E.¹⁷^ORCID

Affiliation:

1. T.E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA.

2. Department of Dermatology and Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

3. The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.

4. Hubei Key Laboratory of Medical Technology on Transplantation, Transplant Center, Institute of Hepatobiliary Diseases, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China.

5. Department of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.

6. Department of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

7. Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

8. Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.

9. Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA 15261, USA.

10. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

11. Cedars-Sinai Comprehensive Transplant Center, Los Angeles, CA 90048, USA.

12. The Scripps Research Institute, La Jolla, CA 92037, USA.

13. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.

Abstract

B cell sensitization to allografts is promoted by graft-derived extracellular vesicles concentrated by specialized macrophages in lymphoid tissues.

Funder

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference72 articles.

1. Antibody-Mediated Rejection of Solid-Organ Allografts

2. Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapies

3. B cells mediate chronic allograft rejection independently of antibody production

4. Posttransplantation production of donor HLA-specific antibodies as a predictor of renal transplant outcome1

5. Frequency and Clinical Implications of Development of Donor-Specific and Non–Donor-Specific HLA Antibodies after Kidney Transplantation

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