Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment

Author:

Wang Shuang1ORCID,Li Feng12ORCID,Ye Tong12ORCID,Wang Jianghua12,Lyu Chengliang1ORCID,Qing Shuang12,Ding Zhaowen12ORCID,Gao Xiaoyong1ORCID,Jia Rongrong3,Yu Di4ORCID,Ren Jun5,Wei Wei12ORCID,Ma Guanghui12ORCID

Affiliation:

1. State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.

2. School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China.

3. Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, PR China.

4. University of Queensland Diamantina Institute, Faculty of Medicine, University of Queensland, Translational Research Institute, Brisbane 4102, Australia.

5. Department of Medical Oncology, Beijing Key Laboratory for Therapeutic Cancer Vaccines, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, PR China.

Abstract

Macrophage-tumor chimeric exosomes inhibit tumor growth in multiple mouse models by stimulating the immune response and tumor microenvironment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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