A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice

Author:

Gao Liang1ORCID,Yu Qian1ORCID,Zhang Huasheng2ORCID,Wang Zhengting3ORCID,Zhang Tianyu3ORCID,Xiang Jinnan1,Yu Shuxiang1,Zhang Shaoyang1ORCID,Wu Hongguang1,Xu Yizhou1,Wang Zhuo1ORCID,Shen Lu1ORCID,Shu Gang4,Chen Ye-Guang5ORCID,Liu Huijuan1ORCID,Shen Lei2ORCID,Li Baojie16ORCID

Affiliation:

1. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.

2. Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

3. Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

4. Guangdong Provincial Key Laboratory of Animal Nutritional Control, South China Agricultural University, Guangzhou 510642, China.

5. State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

6. Institute of Traditional Chinese Medicine and Stem Cell Research, School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Abstract

Resident stromal cells suppress IBD pathogenesis in mice.

Funder

National Natural Science Foundation of China

National Key Scientific Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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