Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans

Author:

Uhl Franziska M.12ORCID,Chen Sophia13,O’Sullivan David4,Edwards-Hicks Joy4ORCID,Richter Gesa5ORCID,Haring Eileen12ORCID,Andrieux Geoffroy67ORCID,Halbach Sebastian8ORCID,Apostolova Petya14ORCID,Büscher Jörg4,Duquesne Sandra1,Melchinger Wolfgang1,Sauer Barbara1,Shoumariyeh Khalid1ORCID,Schmitt-Graeff Annette9ORCID,Kreutz Marina1011ORCID,Lübbert Michael1,Duyster Justus1ORCID,Brummer Tilman78ORCID,Boerries Melanie67ORCID,Madl Tobias512ORCID,Blazar Bruce R.13ORCID,Groß Olaf1415ORCID,Pearce Erika L.4ORCID,Zeiser Robert115ORCID

Affiliation:

1. Department of Internal Medicine I, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.

2. Faculty of Biology, University of Freiburg, Freiburg 79104, Germany.

3. Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

4. Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg 79108, Germany.

5. Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology & Biochemistry, Medical University of Graz, Graz 8010, Austria.

6. Institute of Medical Bioinformatics and Systems Medicine, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79110, Germany.

7. German Cancer Consortium (DKTK), Partner Site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.

8. Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany.

9. University of Freiburg, Freiburg 79085, Germany.

10. Internal Medicine III, University Hospital Regensburg, Regensburg 93042, Germany.

11. Regensburg Center for Interventional Immunology (RCI), Regensburg 93053, Germany.

12. BioTechMed-Graz, Graz 8010, Austria.

13. Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA.

14. Institute of Neuropathology, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.

15. Signalling Research Centres BIOSS and CIBSS–Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg 79106, Germany.

Abstract

Bicarbonate boosts metabolic fitness of T cells challenged with leukemia-derived lactic acid.

Funder

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

European Research Council

Deutsche Forschungsgemeinschaft

Austrian Science Fund

BioTechMed Graz

Austrian Research Promotion Agency

Bundesministerium für Bildung und Forschung

Styrian Government

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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