Targeting cartilage EGFR pathway for osteoarthritis treatment-Reference-Cited by-同舟云学术

Targeting cartilage EGFR pathway for osteoarthritis treatment

Published:2021-01-13 Issue:576 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wei Yulong¹²³^ORCID,Luo Lijun²,Gui Tao¹^ORCID,Yu Feifan⁴,Yan Lesan²^ORCID,Yao Lutian¹^ORCID,Zhong Leilei¹,Yu Wei¹³^ORCID,Han Biao⁵^ORCID,Patel Jay M.¹⁶^ORCID,Liu Jessica F.²^ORCID,Beier Frank⁷^ORCID,Levin Lawrence Scott¹^ORCID,Nelson Charles¹^ORCID,Shao Zengwu³,Han Lin⁵^ORCID,Mauck Robert L.¹²⁶,Tsourkas Andrew²,Ahn Jaimo¹⁸^ORCID,Cheng Zhiliang²^ORCID,Qin Ling¹^ORCID

Affiliation:

1. Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

4. Alphathera LLC, Philadelphia, PA 19146, USA.

5. School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA.

6. Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA 19104, USA.

7. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

8. Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI 48104, USA.

Abstract

EGFR activation by overexpressing HBEGF in cartilage or intra-articular delivery of TGFα nanoparticles attenuates osteoarthritis development in mice.

Funder

National Institute on Aging

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Neurological Disorders and Stroke

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine