Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer-Reference-Cited by-同舟云学术

Characterization of ascites- and tumor-infiltrating γδ T cells reveals distinct repertoires and a beneficial role in ovarian cancer

Published:2021-01-20 Issue:577 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Foord Emelie¹^ORCID,Arruda Lucas C. M.¹^ORCID,Gaballa Ahmed¹²^ORCID,Klynning Charlotte³,Uhlin Michael¹⁴⁵^ORCID

Affiliation:

1. Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden.

2. Department of Clinical Biochemistry, National Liver Institute, Menoufia University, 511 32 Shebin Elkom, Egypt.

3. Department of Gynecological Oncology, Karolinska University Hospital, 171 76 Stockholm, Sweden.

4. Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, 141 86 Stockholm, Sweden.

5. Department of Applied Physics, Royal Institute of Technology, 100 44 Stockholm, Sweden.

Abstract

γδ T cells are clonotypically distinct in ascites and tumors of patients with ovarian cancer and their functionality correlates with clinical outcome.

Funder

Stockholm County Council

Swedish Research Council

Adaptive Biotechnologies

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference65 articles.

1. Epithelial ovarian cancer

2. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

3. Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

4. Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis

5. The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy

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