Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination-Reference-Cited by-同舟云学术

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

Published:2020-07-22 Issue:553 Volume:12 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Suscovich Todd J.¹^ORCID,Fallon Jonathan K.¹^ORCID,Das Jishnu¹^ORCID,Demas Allison R.¹²^ORCID,Crain Jonathan¹,Linde Caitlyn H.¹^ORCID,Michell Ashlin¹^ORCID,Natarajan Harini³^ORCID,Arevalo Claudia¹^ORCID,Broge Thomas¹,Linnekin Thomas¹,Kulkarni Viraj¹^ORCID,Lu Richard¹,Slein Matthew D.¹^ORCID,Luedemann Corinne¹,Marquette Meghan²^ORCID,March Sandra²,Weiner Joshua³^ORCID,Gregory Scott⁴^ORCID,Coccia Margherita⁵^ORCID,Flores-Garcia Yevel⁶,Zavala Fidel⁶^ORCID,Ackerman Margaret E.³^ORCID,Bergmann-Leitner Elke⁷^ORCID,Hendriks Jenny⁸,Sadoff Jerald⁸,Dutta Sheetij⁷,Bhatia Sangeeta N.²⁹¹⁰¹¹¹²^ORCID,Lauffenburger Douglas A.⁹¹³^ORCID,Jongert Erik⁵,Wille-Reece Ulrike⁴,Alter Galit¹^ORCID

Affiliation:

1. Ragon Institute of MGH, Harvard, and MIT, Cambridge, MA 02139, USA.

2. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.

4. PATH’s Malaria Vaccine Initiative, Washington, DC 20001, USA.

5. GSK Vaccine, 1300 Wavre, Belgium.

6. Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

7. Malaria Vaccine Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

8. Janssen Vaccines & Prevention B.V., 2333CN Leiden, Netherlands.

9. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA.

10. Broad Institute, Cambridge, MA 02139, USA.

11. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

12. Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.

13. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

A combination of two Fc antibody features that leverage innate immune function predicts protection from malaria challenge after RTS,S/AS01 vaccination.

Funder

Massachusetts General Hospital

PATH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference91 articles.

1. World Health Organization World Malaria Report 2019 (World Health Organization 2019).

2. How to Contain Artemisinin- and Multidrug-Resistant Falciparum Malaria

3. Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems

4. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study

5. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial

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