Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion-Reference-Cited by-同舟云学术

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion

Published:2021-07-28 Issue:604 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Fan Yuping¹^ORCID,Teng Yan²^ORCID,Loison Fabien²^ORCID,Pang Aiming¹^ORCID,Kasorn Anongnard²^ORCID,Shao Xinqi¹,Zhang Cunling¹,Ren Qian¹,Yu Hongbo³^ORCID,Zheng Yi⁴,Cancelas Jose A.⁴⁵,Manis John²^ORCID,Chai Li²^ORCID,Park Shin-Young²^ORCID,Zhao Li²^ORCID,Xu Yuanfu¹^ORCID,Feng Sizhou¹,Silberstein Leslie E.²^ORCID,Ma Fengxia¹^ORCID,Luo Hongbo R.²^ORCID

Affiliation:

1. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, CAMS Key Laboratory for Prevention and Control of Hematological Disease Treatment Related Infection, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, China.

2. Joint Program in Transfusion Medicine, Department of Pathology, Harvard Medical School; Division of Blood Bank, Department of Laboratory Medicine, Stem Cell Program, Boston Children’s Hospital; and Dana-Farber/Harvard Cancer Center, Boston, MA 02115, USA.

3. Department of Pathology and Laboratory Medicine, VA Boston Healthcare System, 1400 VFW Parkway, West Roxbury, MA 02132, USA.

4. Experimental Hematology and Cancer Biology Research, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.

5. Hoxworth Blood Center, Cincinnati, OH 45267, USA.

Abstract

Survival of neutrophils is prolonged, and their function is preserved by simultaneously targeting multiple cell death pathways.

Funder

National Institutes of Health

Flight Attendant Medical Research Institute

National Natural Sciences Foundation of China

HRL

City University London

Chinese Academy of Medical Sciences