Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair-Reference-Cited by-同舟云学术

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

Published:2021-05-19 Issue:594 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Mylonas Katie J.¹^ORCID,O’Sullivan Eoin D.¹^ORCID,Humphries Duncan¹^ORCID,Baird David P.¹²^ORCID,Docherty Marie-Helena¹,Neely Sarah A.¹³^ORCID,Krimpenfort Paul J.⁴,Melk Anette⁵^ORCID,Schmitt Roland⁵,Ferreira-Gonzalez Sofia³^ORCID,Forbes Stuart J.³^ORCID,Hughes Jeremy¹^ORCID,Ferenbach David A.¹^ORCID

Affiliation:

1. Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.

2. Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK.

3. Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK.

4. Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

5. Hannover Medical School, 30625 Hannover, Germany.

Abstract

Senescent renal epithelia promote fibrosis and functional loss after injury, whereas depletion improves regeneration in aged or irradiated kidneys.

Funder

Wellcome

Kidney Research UK

Publisher