Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide-Reference-Cited by-同舟云学术

Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

Published:2021-05-12 Issue:593 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sishc Brock J.¹^ORCID,Ding Lianghao¹,Nam Taek-Keun¹^ORCID,Heer Collin D.²^ORCID,Rodman Samuel N.²,Schoenfeld Joshua D.²^ORCID,Fath Melissa A.²^ORCID,Saha Debabrata¹,Pulliam Casey F.²^ORCID,Langen Britta¹^ORCID,Beardsley Robert A.³^ORCID,Riley Dennis P.³^ORCID,Keene Jeffery L.³^ORCID,Spitz Douglas R.³^ORCID,Story Michael D.¹^ORCID

Affiliation:

1. Division of Molecular Radiation Biology, Department of Radiation Oncology, and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

2. Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA.

3. Galera Therapeutics Inc., 2 West Liberty Blvd., Suite 110, Malvern, PA 19355, USA.

Abstract

Avasopasem manganese enhances tumor cell killing after ablative hypofractionated radiation through the generation of hydrogen peroxide.

Funder

International Parkinson and Movement Disorder Society

Galera Therapeutics

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference64 articles.

1. Superoxide Dismutase