Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis-Reference-Cited by-同舟云学术

Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis

Published:2021-06-30 Issue:600 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

So Wing Yan¹^ORCID,Liu Wai Nam¹^ORCID,Teo Adrian Kee Keong¹²^ORCID,Rutter Guy A.³,Han Weiping¹⁴^ORCID

Affiliation:

1. Institute of Molecular and Cell Biology, Agency for Science Technology and Research, Singapore 138673, Singapore.

2. Departments of Biochemistry and Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore.

3. Section of Cell Biology and Functional Genomics and Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London W12 0NN, UK.

4. Center for Neuro-Metabolism and Regeneration Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510700, China.

Abstract

PAX6 replenishment improves glucose-stimulated insulin secretion and glucose homeostasis in diabetic mice and primary human islets.

Funder

University of Kentucky

Wellcome

Horizon 2020 Framework Programme

European Federation of Pharmaceutical Industries and Associations

Mauritius Research Council

Young Individual Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference51 articles.

1. Diabetes mellitus and genetically programmed defects in β-cell function

2. The Genetic Basis of Type 2 Diabetes Mellitus: Impaired Insulin Secretion versus Impaired Insulin Sensitivity

3. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.

4. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

5. Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker

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