ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease-Reference-Cited by-同舟云学术

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

Published:2015-10-07 Issue:308 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Jilu¹²³⁴,Ramadan Abdulraouf M.¹²³⁴,Griesenauer Brad¹²³⁴,Li Wei¹²³⁴,Turner Matthew J.²⁵⁶,Liu Chen⁷,Kapur Reuben²,Hanenberg Helmut¹²⁸,Blazar Bruce R.⁹,Tawara Isao¹⁰,Paczesny Sophie¹²³⁴

Affiliation:

1. Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

2. Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

3. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

4. Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

5. Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

6. Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis, IN 46202, USA.

7. Department of Pathology and Immunology, University of Florida College of Medicine, Gainesville, FL 32610, USA.

8. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

9. Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, USA.

10. Department of Hematology/Oncology, Mie University Hospital, Mie 514-8507, Japan.

Abstract

Blocking sST2 before transplant with a neutralizing monoclonal antibody reduced GVHD severity and mortality.

Funder

National Cancer Institute

National Institute of Allergy and Infectious Diseases

National Institute of Diabetes and Digestive and Kidney Diseases

Leukemia & Lymphoma Society Scholar Award

Senshin Medical Research Foundation

Lilly Physician Scientist Initiative Award

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference59 articles.

1. Induction of Tumor Immunity Following Allogeneic Stem Cell Transplantation

2. Graft-versus-leukemia effects of transplantation and donor lymphocytes

3. Dissecting graft-versus-leukemia from graft-versus-host-disease using novel strategies

4. Graft-versus-host disease

5. The biology of graft-versus-host disease: experimental systems instructing clinical practice

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