Quality and quantity of T FH cells are critical for broad antibody development in SHIV AD8 infection-Reference-Cited by-同舟云学术

Quality and quantity of T FH cells are critical for broad antibody development in SHIV AD8 infection

Published:2015-07-29 Issue:298 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yamamoto Takuya¹,Lynch Rebecca M.²,Gautam Rajeev³,Matus-Nicodemos Rodrigo¹,Schmidt Stephen D.²,Boswell Kristin L.¹,Darko Sam⁴,Wong Patrick²,Sheng Zizhang⁵,Petrovas Constantinos¹,McDermott Adrian B.¹,Seder Robert A.⁶,Keele Brandon F.⁷,Shapiro Lawrence⁵,Douek Daniel C.⁴,Nishimura Yoshiaki³,Mascola John R.²,Martin Malcolm A.³,Koup Richard A.¹

Affiliation:

1. Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

2. Humoral Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.

3. Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, MD 20892, USA.

4. Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.

5. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

6. Cellular Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, MD 20892, USA.

7. AIDS and Cancer Virus Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

Abstract

T follicular helper cells associate with development of highly mutated neutralizing antibodies against SHIV.

Funder

NIH

National Cancer Institute

Intramural Research Program of the NIAID

Bill and Melinda Gates Foundation

Intramural Research Program of the Vaccine Research Center

Collaboration for AIDS Vaccine Discovery

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference54 articles.

1. Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning

2. Follicular Helper CD4 T Cells (TFH)

3. CD4 T follicular helper cell dynamics during SIV infection

4. Follicular Helper T Cells: Lineage and Location

5. Molecular programming of B cell memory

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