Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation-Reference-Cited by-同舟云学术

Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation

Published:2015-09-02 Issue:303 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Spence Shaun¹,Greene Michelle K.²,Fay François²³,Hams Emily⁴,Saunders Sean P.⁴,Hamid Umar¹,Fitzgerald Marianne¹,Beck Jonathan¹,Bains Baljinder K.²,Smyth Peter²,Themistou Efrosyni⁵,Small Donna M.¹,Schmid Daniela²,O’Kane Cecilia M.¹,Fitzgerald Denise C.¹,Abdelghany Sharif M.²⁶,Johnston James A.¹⁷,Fallon Padraic G.⁴⁸,Burrows James F.²,McAuley Daniel F.¹,Kissenpfennig Adrien¹,Scott Christopher J.²

Affiliation:

1. Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast BT9 7AE, UK.

2. School of Pharmacy, Queen’s University Belfast, Belfast BT9 7BL, UK.

3. Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

4. Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.

5. School of Chemistry and Chemical Engineering, Queen’s University Belfast, Belfast BT9 5AG, UK.

6. Faculty of Pharmacy, University of Jordan, Amman 11942, Jordan.

7. Inflammation Research, Amgen Inc., Thousand Oaks, CA 91320, USA.

8. National Children’s Research Centre, Our Lady’s Children’s Hospital, Dublin 12, Ireland.

Abstract

A nanoparticle coated with sialic acid activates Siglec receptors on macrophages, improving survival from sepsis in mice and reducing inflammation in human tissues.

Funder

Medical Research Council

Health and Social Care Northern Ireland R&D Division Translational Research Group for Critical Care

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference53 articles.

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