HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition-Reference-Cited by-同舟云学术

HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition

Published:2015-07-15 Issue:296 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Prentice Heather A.¹²,Tomaras Georgia D.³,Geraghty Daniel E.⁴,Apps Richard⁵,Fong Youyi⁶,Ehrenberg Philip K.¹,Rolland Morgane¹²,Kijak Gustavo H.¹²,Krebs Shelly J.¹²,Nelson Wyatt⁴,DeCamp Allan⁶,Shen Xiaoying³,Yates Nicole L.³,Zolla-Pazner Susan⁷,Nitayaphan Sorachai⁸,Rerks-Ngarm Supachai⁹,Kaewkungwal Jaranit¹⁰,Pitisuttithum Punnee¹¹,Ferrari Guido³,McElrath M. Juliana⁶,Montefiori David C.³,Bailer Robert T.¹²,Koup Richard A.¹²,O’Connell Robert J.⁸,Robb Merlin L.¹²,Michael Nelson L.¹,Gilbert Peter B.⁶,Kim Jerome H.¹,Thomas Rasmi¹²

Affiliation:

1. U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

2. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20818, USA.

3. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA.

4. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

5. Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

6. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

7. Veterans Affairs New York Harbor Healthcare System and the Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

8. Department of Retrovirology, U.S. Army Medical Component, Armed Forces Research Institute Medical Sciences, Bangkok 10400, Thailand.

9. Department of Disease Control, Ministry of Public Health, Nonthaburi 11000, Thailand.

10. Center of Excellence for Biomedical and Public Health Informatics (BIOPHICS), Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

11. Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

12. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

HLA class II modulated the quantity, quality, and efficacy of antibody responses in the RV144 HIV vaccine trial.

Funder

NIH

U.S. Department of Defense

NIAID

U.S. National Institute of Allergy and Infectious Disease

Bill & Melinda Gates Foundation

Henry M. Jackson Foundation for the Advancement of Military Medicine Inc.

Duke Center for AIDS Research