An actuatable soft reservoir modulates host foreign body response

Author:

Dolan E. B.123ORCID,Varela C. E.14ORCID,Mendez K.14,Whyte W.1567ORCID,Levey R. E.3,Robinson S. T.367ORCID,Maye E.3ORCID,O’Dwyer J.23,Beatty R.3,Rothman A.8ORCID,Fan Y.8ORCID,Hochstein J.4,Rothenbucher S. E.1,Wylie R.3ORCID,Starr J. R.9ORCID,Monaghan M.510ORCID,Dockery P.310ORCID,Duffy G. P.356710ORCID,Roche E. T.18ORCID

Affiliation:

1. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.

2. Biomedical Engineering, College of Engineering and Informatics, National University of Ireland Galway, Galway, Ireland.

3. Anatomy and Regenerative Medicine Institute (REMEDI), School of Medicine, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

4. Harvard-MIT Program in Health Sciences and Technology, Cambridge, MA, USA.

5. Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

6. Advanced Materials and BioEngineering Research Centre (AMBER), Trinity College Dublin, Dublin, Ireland.

7. Royal College of Surgeons in Ireland, Dublin, Ireland.

8. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

9. Epidemiology and Biostatistics Core, The Forsyth Institute, 245 First Street, Cambridge, MA, USA.

10. CÚRAM, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.

Abstract

The foreign body response is modulated by a dynamic soft reservoir by altering the biomechanics of the peri-implant tissue.

Funder

Science Foundation Ireland

National Science Foundation Graduate Research Fellowship Program

Mechanical Engineering Department and the Institute for Medical Engineering and Science at the Massachusetts Institute of Technology

The DRIVE project which has received funding from the European Union’s Horizon 2020 research and innovation programme

European Molecular Biology Organization Short Term Fellowship

European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Artificial Intelligence,Control and Optimization,Computer Science Applications,Mechanical Engineering

Reference63 articles.

1. Invasive intraneural interfaces: Foreign body reaction issues;Lotti F.;Front. Neurosci.,2017

2. Brain tissue responses to neural implants impact signal sensitivity and intervention strategies;Kozai T. D. Y.;ACS Chem. Nerosci.,2014

3. Foreign body reaction to dialysis chatheter and peritoneal fluid eosinophilia in a child on continuous ambulatory peritoneal dialysis;Cetin N.;Iran. J. Kidney Dis.,2017

4. Comparison of the postoperative incidence rate of capsular contracture among different breast implants: A cumulative meta-analysis;Liu X.;PLOS ONE,2015

5. Cardiac implantable electronic device infection in patients at risk;Tarakji K. G.;Arrhythmia Electrophysiol. Rev.,2016

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