The Persistence of Senescence-Reference-Cited by-同舟云学术

The Persistence of Senescence

Published:2003-08-20 Issue:33 Volume:2003 Page:
ISSN:1539-6150
Container-title:Science of Aging Knowledge Environment
language:en
Short-container-title:Sci. Aging Knowl. Environ.

Author:

Sharpless Norman E.¹

Affiliation:

1. The author is in the Departments of Medicine and Genetics, Lineberger Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

Abstract

Senescence is a potent anticancer mechanism, representing a barrier that most, if not all, would-be tumor cells must traverse on their path to malignant transformation. In this Perspective, I discuss two recent publications ( 1 , 2 ) that deal with the durability of senescence. These findings are of interest not only to those who study aging, but to those who study cancer as well.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference28 articles.

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5. G. H. Stein, L. F. Drullinger, A. Soulard, V. Dulic, Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol. Cell. Biol. 19, 2109-2117 (1999).

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