Ceramide, Stress, and a "LAG" in Aging-Reference-Cited by-同舟云学术

Ceramide, Stress, and a "LAG" in Aging

Published:2003-10 Issue:39 Volume:2003 Page:
ISSN:1539-6150
Container-title:Science of Aging Knowledge Environment
language:en
Short-container-title:Sci. Aging Knowl. Environ.

Author:

Obeid Lina M.¹,Hannun Yusuf A.¹

Affiliation:

1. Lina M. Obeid is in the Ralph H. Johnson Veterans Affairs Medical Center, Department of Veteran Affairs, Charleston, SC 29401, USA; the Department of Medicine, Division of General Internal Medicine, University of South Carolina, Charleston, SC 29425, USA; and the Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA. Yusuf A. Hannun is in the Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston,...

Abstract

Recent studies have implicated the longevity assurance gene LAG1 in ceramide synthesis. In light of a role for ceramide in yeast and mammalian stress responses and mammalian cellular senescence, important connections are emerging between ceramide and organismal aging. In this Perspective, we examine the evidence for these connections in yeast, Drosophila , and mammals, and speculate on their implications.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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