The Development of Amyloid β Protein Deposits in the Aged Brain-Reference-Cited by-同舟云学术

The Development of Amyloid β Protein Deposits in the Aged Brain

Published:2006-03-08 Issue:6 Volume:2006 Page:
ISSN:1539-6150
Container-title:Science of Aging Knowledge Environment
language:en
Short-container-title:Sci. Aging Knowl. Environ.

Author:

Thal Dietmar R.¹,Capetillo-Zarate Estibaliz¹,Del Tredici Kelly¹,Braak Heiko¹

Affiliation:

1. The authors are at the Department of Neuropathology, University of Bonn, D-53105 Bonn, Germany (D.R.T. and E.C.-Z.) and at the Institute for Clinical Neuroanatomy, J. W. Goethe University, D-60590 Frankfurt am Main, Germany (K.D.T. and H.B.).(D.R.T.)

Abstract

The deposition of amyloid β protein (Aβ) in the human brain and the generation of neurofibrillary tangles are the histopathological hallmarks of Alzheimer's disease. Accumulation of Aβ takes place in senile plaques and in cerebrovascular deposits as a result of an imbalance between Aβ production and clearance. This Review describes the different types of Aβ deposits, which can be distinguished by their morphology and by the hierarchical involvement of distinct areas of the brain in Aβ deposition. The role of intracellular Aβ in Aβ deposition and the mechanism of Aβ toxicity are also discussed.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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