Sperm DNA damage causes genomic instability in early embryonic development-Reference-Cited by-同舟云学术

Sperm DNA damage causes genomic instability in early embryonic development

Published:2020-04-17 Issue:16 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Middelkamp Sjors¹^ORCID,van Tol Helena T. A.²,Spierings Diana C. J.³^ORCID,Boymans Sander¹^ORCID,Guryev Victor³^ORCID,Roelen Bernard A. J.²^ORCID,Lansdorp Peter M.³⁴⁵,Cuppen Edwin¹⁶^ORCID,Kuijk Ewart W.¹^ORCID

Affiliation:

1. Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, Utrecht 3584 CG, Netherlands.

2. Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 104, Utrecht 3584 CM, Netherlands.

3. European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, Netherlands.

4. Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

5. Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.

6. Hartwig Medical Foundation, Amsterdam, Netherlands.

Abstract

Sperm cells with damaged DNA cause mitotic errors in the fertilized embryo, leading to a diverse spectrum of genomic abnormalities.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference56 articles.

1. Evidence that human blastomere cleavage is under unique cell cycle control

2. Human gene expression first occurs between the four- and eight-cell stages of preimplantation development