Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

Author:

Cachot Amélie1ORCID,Bilous Mariia12ORCID,Liu Yen-Cheng3ORCID,Li Xiaokang3ORCID,Saillard Margaux1ORCID,Cenerenti Mara45,Rockinger Georg Alexander1ORCID,Wyss Tania12ORCID,Guillaume Philippe1,Schmidt Julien1,Genolet Raphaël1ORCID,Ercolano Giuseppe45,Protti Maria Pia6ORCID,Reith Walter4,Ioannidou Kalliopi7ORCID,de Leval Laurence7ORCID,Trapani Joseph A.8,Coukos George1ORCID,Harari Alexandre1ORCID,Speiser Daniel E.1,Mathis Alexander91011ORCID,Gfeller David12ORCID,Altug Hatice3ORCID,Romero Pedro1ORCID,Jandus Camilla45ORCID

Affiliation:

1. Department of Oncology and Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, CH-1066, Switzerland.

2. Swiss Institute of Bioinformatics, Lausanne, CH-1015, Switzerland.

3. Institute of Bioengineering, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland.

4. Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, CH-1211, Switzerland.

5. Ludwig Institute for Cancer Research, Lausanne Branch, Lausanne, CH-1066, Switzerland.

6. Tumor Immunology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Raffaele Scientific Institute, Milan, Italy.

7. Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, CH-1011, Switzerland.

8. Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne 3000, Australia.

9. Harvard University, Cambridge, MA, USA.

10. Center for Neuroprosthetics, Center for Intelligent Systems, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.

11. Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, CH-1015, Switzerland.

Abstract

Fully functional, tumor-specific, SLAMF7-expressing cytotoxic CD4 T cells directly mediate immunity against human cancer.

Funder

Ludwig Institute for Cancer Research

Chan Zuckerberg Initiative

Swiss National Science Foundation

MEDIC Foundation

SAV-Novartis Consumer Health Fund

ISREC Foundation

Fondazione San Salvatore

Olga Mayenfish Foundation

Taiwan EPFL PhD scholarship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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