Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning-Reference-Cited by-同舟云学术

Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning

Published:2020-07-24 Issue:30 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Summerbell Emily R.¹^ORCID,Mouw Janna K.²³^ORCID,Bell Joshua S. K.⁴,Knippler Christina M.²³,Pedro Brian¹^ORCID,Arnst Jamie L.²³,Khatib Tala O.⁵,Commander Rachel¹,Barwick Benjamin G.²³^ORCID,Konen Jessica¹,Dwivedi Bhakti³,Seby Sandra³,Kowalski Jeanne³⁶^ORCID,Vertino Paula M.³⁷,Marcus Adam I.²³^ORCID

Affiliation:

1. Graduate Program in Cancer Biology, Emory University, Atlanta, GA, USA.

2. Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA.

3. Winship Cancer Institute, Emory University, Atlanta, GA, USA.

4. Graduate Program in Genetics and Molecular Biology, Emory University, Atlanta, GA, USA.

5. Graduate Program in Biochemistry, Cell and Developmental Biology, Emory University, Atlanta, GA, USA.

6. Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.

7. Department of Radiation Oncology, Emory University, Atlanta, GA, USA.

Abstract

Specialized leader cells use stable filopodia to create linear fibronectin tracks to promote collective cancer invasion.

Funder

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

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3. Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis

4. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

5. Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

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