Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2

Author:

Rodrigues Kristen A.1234ORCID,Rodriguez-Aponte Sergio A.15ORCID,Dalvie Neil C.16ORCID,Lee Jeong Hyun47ORCID,Abraham Wuhbet13,Carnathan Diane G.489,Jimenez Luis E.89,Ngo Julia T.89ORCID,Chang Jason Y. H.13ORCID,Zhang Zeli47,Yu Jingyou10ORCID,Chang Aiquan1011ORCID,Nakao Catherine7ORCID,Goodwin Benjamin7ORCID,Naranjo Christopher A.1,Zhang Libin13,Silva Murillo134ORCID,Barouch Dan H.310ORCID,Silvestri Guido489ORCID,Crotty Shane47ORCID,Love J. Christopher16ORCID,Irvine Darrell J.134512ORCID

Affiliation:

1. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Harvard-MIT Health Sciences and Technology Program, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.

4. Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.

5. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

6. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

7. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

8. Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA.

9. Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA.

10. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

11. Harvard Medical School, Boston, MA 02215, USA.

12. Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Coanchoring a SARS-CoV-2 immunogen and molecular adjuvants to alum extends vaccine kinetics and amplifies humoral immunity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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