The chaperonin CCT controls T cell receptor–driven 3D configuration of centrioles

Author:

Martin-Cofreces N. B.123ORCID,Chichon F. J.4ORCID,Calvo E.35ORCID,Torralba D.12ORCID,Bustos-Moran E.12ORCID,Dosil S. G.12ORCID,Rojas-Gomez A.12ORCID,Bonzon-Kulichenko E.35ORCID,Lopez J. A.5ORCID,Otón J.6ORCID,Sorrentino A.7ORCID,Zabala J. C.8,Vernos I.91011ORCID,Vazquez J.35ORCID,Valpuesta J. M.4ORCID,Sanchez-Madrid F.123ORCID

Affiliation:

1. Immunology Service, Hospital Universitario de la Princesa, UAM, IIS-IP. Madrid, 28006 Spain.

2. Area of Vascular Pathophysiology, Laboratory of Intercellular Communication, Fundación Centro Nacional de Investigaciones Cardiovasculares-Carlos III, Madrid, 28029 Spain.

3. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Spain.

4. Department of Macromolecular Structure, Computational Systems Biology Group, Centro Nacional de Biotecnología (CNB-CSIC), Madrid, 28049, Spain.

5. Laboratory of Cardiovascular Proteomics. Fundación Centro Nacional de Investigaciones Cardiovasculares-Carlos III, Madrid, 28029 Spain.

6. Structural Studies Division, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

7. ALBA Synchrotron Light Source, Cerdanyola del Vallès, Barcelona 08290, Spain.

8. Departament of Molecular Biology, Facultad de Medicina, Universidad de Cantabria, Santander, 39005 Spain.

9. Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr Aiguader 88, Barcelona, 08003, Spain.

10. Universitat Pompeu Fabra (UPF), Dr Aiguader 88, Barcelona 08003, Spain.

11. ICREA, Pg. Lluis Companys 23, Barcelona 08010, Spain.

Abstract

Eukaryotic chaperonin-containing TCP1 drives tubulin dynamics and centrosome structure at immune synaptic contacts.

Funder

European Research Council

Spanish Ministry of Economy and Competitiveness

ALBA Synchrotron standard proposals

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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