Odontoblast TRPC5 channels signal cold pain in teeth

Author:

Bernal Laura12ORCID,Sotelo-Hitschfeld Pamela13ORCID,König Christine1,Sinica Viktor14,Wyatt Amanda5ORCID,Winter Zoltan1ORCID,Hein Alexander6ORCID,Touska Filip14,Reinhardt Susanne7ORCID,Tragl Aaron1,Kusuda Ricardo1ORCID,Wartenberg Philipp5,Sclaroff Allen8ORCID,Pfeifer John D.9ORCID,Ectors Fabien10ORCID,Dahl Andreas7,Freichel Marc11ORCID,Vlachova Viktorie4ORCID,Brauchi Sebastian312,Roza Carolina2ORCID,Boehm Ulrich5ORCID,Clapham David E.6ORCID,Lennerz Jochen K.13ORCID,Zimmermann Katharina1ORCID

Affiliation:

1. Department of Anesthesiology, Erlangen University Hospital, Friedrich Alexander University of Erlangen-Nuremberg (FAU), Erlangen, Germany.

2. Departamento de Biología de Sistemas, Facultad de Medicina, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

3. Institute of Physiology, Faculty of Medicine and Center for Interdisciplinary Studies on the Nervous System (CISNe), Universidad Austral de Chile, Valdivia, Chile.

4. Department of Cellular Neurophysiology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.

5. Experimental Pharmacology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.

6. HHMI, Cardiovascular Division, Boston Children’s Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

7. Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.

8. Department of Otolaryngology, Washington University School of Medicine, St Louis, MO, USA.

9. Department of Pathology, Washington University School of Medicine, St Louis, MO, USA.

10. FARAH Mammalian Transgenics Platform, Liège University, Liège, Belgium.

11. Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany.

12. Millennium Nucleus of Ion Channel-associated Diseases (MiNICAD), Santiago, Chile.

13. Center for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

Abstract

The odontoblast, with processes beyond the dentin-enamel boundary, is the initial site of TRPC5 cold transduction in teeth.

Funder

Deutsche Forschungsgemeinschaft

Agencia Nacional de Investigación y Desarrollo

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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