1. Department of Pharmacology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
2. Research Fellow of the Japan Society for the Promotion of Science (JSPS), Chiyoda-Ku, Tokyo 102-0083, Japan.
3. Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
4. Central Institute for Experimental Animals, Kawasaki, Kanagawa 210-0821, Japan.
5. KAGAMI Inc., Ibaraki, Osaka 567-0085, Japan.
6. Department of Drug Discovery and Evolution, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
7. Howard Hughes Medical Institute and Harvard Medical School, Boston, MA 02115, USA.