Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice-Reference-Cited by-同舟云学术

Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in mice

Published:2021-12-03 Issue:49 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Mabrouk Moustafa T.¹^ORCID,Chiem Kevin²,Rujas Edurne³⁴^ORCID,Huang Wei-Chiao¹,Jahagirdar Dushyant⁵^ORCID,Quinn Breandan¹^ORCID,Surendran Nair Meera⁶^ORCID,Nissly Ruth H.⁶^ORCID,Cavener Victoria S.⁶,Boyle Nina R.⁶^ORCID,Sornberger Ty A.⁶^ORCID,Kuchipudi Suresh V.⁶^ORCID,Ortega Joaquin⁵,Julien Jean-Philippe³⁷^ORCID,Martinez-Sobrido Luis²^ORCID,Lovell Jonathan¹^ORCID

Affiliation:

1. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.

2. Texas Biomedical Research Institute, San Antonio, TX 78227, USA.

3. Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.

4. Biofisika Institute (CSIC, UPV/EHU) and Department of Biochemistry and Molecular Biology, University of the Basque Country (UPV/EHU), Bilbao, Spain.

5. Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 0C7, Canada.

6. Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA.

7. Departments of Biochemistry and Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.

Abstract

SARS-CoV-2 antigens that are displayed on liposomes and lyophilized are thermostable and protect mice from lethal virus challenge.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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