Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome–dependent interleukin-1β production-Reference-Cited by-同舟云学术

Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome–dependent interleukin-1β production

Published:2021-12-10 Issue:50 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Gu Ping¹²³^ORCID,Hui Xiaoyan¹²⁴^ORCID,Zheng Qiantao⁵⁶^ORCID,Gao Yuan¹²,Jin Leigang¹²^ORCID,Jiang Weimin⁷,Zhou Changsheng⁸,Liu Tianxia⁵⁶,Huang Yu⁴⁹^ORCID,Liu Qing¹²,Nie Tao¹⁰,Wang Yanfang¹¹,Wang Yu¹¹²^ORCID,Zhao Jianguo⁵⁶^ORCID,Xu Aimin¹²¹²^ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China.

2. Department of Medicine, University of Hong Kong, Hong Kong, China.

3. Department of Endocrinology, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, China.

4. School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, China.

5. State Key Laboratory of Stem Cell and Reproductive Biology, Chinese Academy of Sciences, Chaoyang District, Beijing, China.

6. Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.

7. Department of Cardiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, China.

8. Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

9. Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.

10. Clinical Department of Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

11. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.

12. Department of Pharmacy and Pharmacology, University of Hong Kong, Hong Kong, China.

Abstract

The mitochondrial protein UCP1 has potent therapeutic effects on vascular inflammation and atherosclerosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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