Motor training improves coordination and anxiety in symptomatic Mecp2 -null mice despite impaired functional connectivity within the motor circuit-Reference-Cited by-同舟云学术

Motor training improves coordination and anxiety in symptomatic Mecp2 -null mice despite impaired functional connectivity within the motor circuit

Published:2021-10-22 Issue:43 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Yue Yuanlei¹^ORCID,Xu Pan¹^ORCID,Liu Zhichao²^ORCID,Sun Xiaoqian³,Su Juntao⁴,Du Hongfei⁴^ORCID,Chen Lingling¹,Ash Ryan T.⁵,Smirnakis Stelios⁶,Simha Rahul³^ORCID,Kusner Linda¹^ORCID,Zeng Chen²^ORCID,Lu Hui¹^ORCID

Affiliation:

1. Department of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, Washington, DC 20037, USA.

2. Department of Physics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA.

3. Department of Computer Science, School of Engineering and Applied Science, The George Washington University, Washington, DC 20037, USA.

4. Department of Statistics, Columbian College of Arts and Sciences, The George Washington University, Washington, DC 20037, USA.

5. Department of Psychiatry, Stanford University, Palo Alto, CA 94305, USA.

6. Department of Neurology, Brigham and Women’s Hospital, Jamaica Plain VA Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Even symptomatic Mecp2 -null mice can develop motor skills, which improve behavior and extend life span by 20%.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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