Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

Author:

Rocha Andréa Livia1234ORCID,de Lima Tanes Imamura567ORCID,de Souza Gerson Profeta125ORCID,Corrêa Renan Oliveira28ORCID,Ferrucci Danilo Lopes169ORCID,Rodrigues Bruno10ORCID,Lopes-Ramos Camila1112ORCID,Nilsson Daniel1314ORCID,Knittel Thiago Leite125ORCID,Castro Pollyana Ribeiro28ORCID,Fernandes Mariane Font28ORCID,dos Santos Martins Flaviano15ORCID,Parmigiani Raphael Bessa11ORCID,Silveira Leonardo Reis56ORCID,Carvalho Hernandes F.69ORCID,Auwerx Johan7ORCID,Vinolo Marco Aurélio R.25816ORCID,Boucher Jeremie131417ORCID,Mori Marcelo A.12345ORCID

Affiliation:

1. Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, Brazil.

2. Program in Genetics and Molecular Biology, Institute of Biology, University of Campinas, Campinas, Brazil.

3. Department of Biophysics, São Paulo School of Medicine, Federal University of São Paulo, São Paulo, Brazil.

4. Program in Biotechnology, Federal University of São Paulo, São Paulo, Brazil.

5. Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil.

6. Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, Brazil.

7. Laboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

8. Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.

9. National Institute of Science and Technology in Photonics Applied to Cell Biology (INFABiC), University of Campinas, Campinas, Brazil.

10. Department of Adapted Physical Activity, School of Physical Education, University of Campinas, Campinas, Brazil.

11. Center of Molecular Oncology, Sírio-Libanês Hospital, São Paulo, Brazil.

12. Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, USA.

13. Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Sweden.

14. The Lundberg Laboratory for Diabetes Research, University of Gothenburg, Sweden.

15. Laboratory of Biotherapeutics Agents, Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.

16. Experimental Medicine Research Cluster (EMRC), Campinas, Brazil.

17. Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Abstract

Enoxacin mitigates obesity by inducing fat and muscle energy metabolism independently of its antibiotic function.

Funder

Coordenao de Aperfeioamento de Pessoal de Nvel Superior

Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico

Fundao de Amparo Pesquisa do Estado de So Paulo

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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