Parabrachial neuron types categorically encode thermoregulation variables during heat defense

Author:

Yang Wen Z.12ORCID,Du Xiaosa134ORCID,Zhang Wen3ORCID,Gao Cuicui134ORCID,Xie Hengchang134,Xiao Yan56ORCID,Jia Xiaoning1,Liu Jiashu1,Xu Jianhui7,Fu Xin134,Tu Hongqing134ORCID,Fu Xiaoyu134,Ni Xinyan1,He Miao8ORCID,Yang Jiajun56ORCID,Wang Hong9,Yang Haitao1ORCID,Xu Xiao-hong3ORCID,Shen Wei L.1ORCID

Affiliation:

1. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, Shanghaitech University, Shanghai 201210, China.

2. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

3. Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.

4. University of Chinese Academy of Sciences, Beijing 100049, China.

5. Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China.

6. Department of Neurology, Shanghai Sixth People’s Hospital East Affiliated to Shanghai University of Medicine and Health Science, 222 West Third Road, Huanhu, Shanghai 201306, China.

7. Thermoregulation and Inflammation Laboratory, Chengdu Medical College, Chengdu Sichuan 610500, China.

8. Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200032, China.

9. Shenzhen Key Laboratory of Drug Addiction, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen 518055, China.

Abstract

Two key brainstem neuron types were identified for heat defense, fever limiting, energy expenditure, and body weight control.

Funder

National Key Research and Development Program of China Stem Cell and Translational Research

National Nature Science Foundation of China

Shanghai Science and Technology Committee of Shanghai City

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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