Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases

Author:

Trapecar Martin1ORCID,Wogram Emile2,Svoboda Devon2,Communal Catherine1,Omer Attya2ORCID,Lungjangwa Tenzin2,Sphabmixay Pierre23,Velazquez Jason1ORCID,Schneider Kirsten1,Wright Charles W.1,Mildrum Samuel145ORCID,Hendricks Austin145ORCID,Levine Stuart145ORCID,Muffat Julien2ORCID,Lee Meelim Jasmine1,Lauffenburger Douglas A.16ORCID,Trumper David36ORCID,Jaenisch Rudolf25ORCID,Griffith Linda G.137ORCID

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

2. Whitehead Institute for Biomedical Research, Cambridge, MA, USA.

3. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

4. MIT BioMicro Center, Cambridge, MA, USA.

5. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

6. Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.

7. Center for Gynepathology Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

Abstract

Engineered model of the human gut-liver-brain axis can be used to study the link between the microbiome and Parkinson’s disease.

Funder

National Cancer Institute

National Institute of Environmental Health Sciences

Defense Sciences Office, DARPA

Korea National Institute of Health

Army Research Office Institute for Collaborative Biotechnologies

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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