Cardiac cell type–specific gene regulatory programs and disease risk association

Author:

Hocker James D.123ORCID,Poirion Olivier B.4,Zhu Fugui5ORCID,Buchanan Justin4ORCID,Zhang Kai3ORCID,Chiou Joshua26ORCID,Wang Tsui-Min7,Zhang Qingquan5ORCID,Hou Xiaomeng4ORCID,Li Yang E.3ORCID,Zhang Yanxiao3ORCID,Farah Elie N.25ORCID,Wang Allen4,McCulloch Andrew D.78,Gaulton Kyle J.69ORCID,Ren Bing34910ORCID,Chi Neil C.510ORCID,Preissl Sebastian4ORCID

Affiliation:

1. Medical Scientist Training Program, University of California, San Diego, La Jolla, CA, USA.

2. Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.

3. Ludwig Institute for Cancer Research, La Jolla, CA, USA.

4. Center for Epigenomics, University of California, San Diego, La Jolla, CA, USA.

5. Division of Cardiology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

6. Department of Pediatrics, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, CA, USA.

7. Departments of Bioengineering and Medicine, University of California, San Diego, La Jolla, CA, USA.

8. Institute for Engineering in Medicine, University of California, San Diego, La Jolla, CA, USA.

9. Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.

10. Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, USA.

Abstract

A human heart cell type–specific cis-regulatory element atlas reveals gene regulatory mechanisms of cardiovascular diseases.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference141 articles.

1. WHO Cardiovascular Diseases (CVDs) (2017). The World Health Organization https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds).

2. Integrative analysis of 111 reference human epigenomes

3. An integrated encyclopedia of DNA elements in the human genome

4. The accessible chromatin landscape of the human genome

5. Expanded encyclopaedias of DNA elements in the human and mouse genomes

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