SARS-CoV-2 can recruit a heme metabolite to evade antibody immunity

Author:

Rosa Annachiara1ORCID,Pye Valerie E.1ORCID,Graham Carl2,Muir Luke3ORCID,Seow Jeffrey2ORCID,Ng Kevin W.4ORCID,Cook Nicola J.1ORCID,Rees-Spear Chloe3ORCID,Parker Eleanor5,dos Santos Mariana Silva6ORCID,Rosadas Carolina5ORCID,Susana Alberto7,Rhys Hefin8,Nans Andrea9ORCID,Masino Laura9ORCID,Roustan Chloe9ORCID,Christodoulou Evangelos9,Ulferts Rachel10ORCID,Wrobel Antoni G.11ORCID,Short Charlotte-Eve5ORCID,Fertleman Michael12ORCID,Sanders Rogier W.1314ORCID,Heaney Judith1516,Spyer Moira151617ORCID,Kjær Svend9ORCID,Riddell Andy8,Malim Michael H.2,Beale Rupert10ORCID,MacRae James I.6ORCID,Taylor Graham P.5ORCID,Nastouli Eleni151617,van Gils Marit J.13ORCID,Rosenthal Peter B.18ORCID,Pizzato Massimo7ORCID,McClure Myra O.5,Tedder Richard S.5ORCID,Kassiotis George45ORCID,McCoy Laura E.3ORCID,Doores Katie J.2ORCID,Cherepanov Peter15ORCID

Affiliation:

1. Chromatin Structure and Mobile DNA Laboratory, The Francis Crick Institute, London, UK.

2. Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, UK.

3. Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, London, UK.

4. Retroviral Immunology Laboratory, The Francis Crick Institute, London, UK.

5. Department of Infectious Disease, St. Mary’s Campus, Imperial College London, London, UK.

6. Metabolomics Science Technology Platform, The Francis Crick Institute, London, UK.

7. Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.

8. Flow Cytometry Science and Technology Platform, The Francis Crick Institute, London, UK.

9. Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK.

10. Cell Biology of Infection Laboratory, The Francis Crick Institute, London, UK.

11. Structural Biology of Disease Processes Laboratory, The Francis Crick Institute, London, UK.

12. Cutrale Perioperative and Ageing Group, Imperial College London, London, UK.

13. Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam Institute for Infection and Immunity, Amsterdam, Netherlands.

14. Weill Medical College of Cornell University, New York, NY, USA.

15. Advanced Pathogen Diagnostic Unit, University College London Hospitals NHS Foundation Trust, London, UK.

16. Crick COVID-19 Consortium, The Francis Crick Institute, London, UK.

17. Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health.

18. Structural Biology of Cells and Viruses Laboratory, The Francis Crick Institute, London, UK.

Abstract

SARS-CoV-2 spike N-terminal domain harbors a potent epitope that can be modulated by binding of natural linear tetrapyrroles.

Funder

National Institutes of Health

Wellcome

Francis Crick Institute

Medical Research Council

Kings Together Rapid COVID-19 Call award

Huo Family Foundation

European and Developing Countries Clinical Trials Partnership

Cancer Research UK

Netherlands Organization for Scientific Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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