Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer

Author:

Hedegaard Clara Louise12ORCID,Redondo-Gómez Carlos12ORCID,Tan Bee Yi3,Ng Kee Woei3456ORCID,Loessner Daniela789ORCID,Mata Alvaro12101112ORCID

Affiliation:

1. School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, E1 4NS London, UK.

2. Institute of Bioengineering, Queen Mary University of London, Mile End Road, E1 4NS London, UK.

3. School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.

4. Environmental Chemistry and Materials Centre, Nanyang Environment & Water Research Institute, Singapore 637141, Singapore.

5. Skin Research Institute of Singapore, Singapore 138648, Singapore.

6. Department of Environmental Health, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.

7. Centre for Tumour Microenvironment, Barts Cancer Institute, Queen Mary University of London, EC1M 6BQ London, UK.

8. Department of Chemical Engineering and Department of Materials Science and Engineering, Faculty of Engineering, Monash University, Melbourne, VIC 3800, Australia.

9. Department of Anatomy and Developmental Biology, Faculty of Medicine, Monash University, Melbourne, VIC 3800, Australia.

10. School of Pharmacy, University of Nottingham, NG7 2RD Nottingham, UK.

11. Department of Chemical and Environmental Engineering, University of Nottingham, NG7 2RD Nottingham, UK.

12. Biodiscovery Institute, University of Nottingham, NG7 2RD Nottingham, UK.

Abstract

Bioengineered matrices from self-assembling peptides and extracellular matrix proteins can model the tumor microenvironment.

Funder

ERC Starting Grant

Program for Innovation and Human Capital from the Ministry of Science, Technology, and Telecommunications of the Government of Costa Rica

UKRMP2 Smart Materials Hub

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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