A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues

Author:

Cassidy Ryan M.123ORCID,Lu Yungang1ORCID,Jere Madhavi4ORCID,Tian Jin-Bin15,Xu Yuanzhong1ORCID,Mangieri Leandra R.13,Felix-Okoroji Blessing6,Selever Jennifer789,Xu Yong10,Arenkiel Benjamin R.789,Tong Qingchun1311ORCID

Affiliation:

1. Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, UTHealth McGovern Medical School, 7000 Fannin St., Houston, TX 77030, USA.

2. MSTP, The University of Texas McGovern Medical School and MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, 6767 Bertner Avenue S3.8344 Mitchell BSRB, Houston, TX 77030, USA.

3. Neuroscience Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, 6767 Bertner Avenue S3.8344 Mitchell BSRB, Houston, TX 77030, USA.

4. Vassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA.

5. Department of Integrative Biology and Pharmacology, UTHealth McGovern Medical School, 6431 Fannin St., Houston, TX 77030-1892, USA.

6. Rice University, 6100 Main St., Houston, TX 77005-1892, USA.

7. Intellectual and Developmental Disabilities Research Center, Neuroconnectivity Core, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

8. Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, S640, Houston, TX 77030, USA.

9. Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, 6621 Fannin St., Houston, TX 77030, USA.

10. Children’s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030, USA.

11. Department of Neurobiology and Anatomy, UTHealth McGovern Medical School, 6431 Fannin St., Suite MSB 7.046 Houston, TX 77030, USA.

Abstract

LH GABA action on anxiogenic stimulus-responsive DBB GABA neurons allows indiscriminate feeding.

Funder

National Institutes of Health

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Drug Abuse

Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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