Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V o complex-Reference-Cited by-同舟云学术

Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V o complex

Published:2020-10-09 Issue:41 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Roh Soung-Hun¹^ORCID,Shekhar Mrinal²³^ORCID,Pintilie Grigore⁴^ORCID,Chipot Christophe³⁵^ORCID,Wilkens Stephan⁶^ORCID,Singharoy Abhishek²^ORCID,Chiu Wah⁴⁷^ORCID

Affiliation:

1. School of Biological Sciences, Seoul National University, Seoul 08826, South Korea.

2. Biodesign Institute, School of Molecular Sciences, Arizona State University, Tempe, AZ 85801, USA.

3. Department of Physics, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

4. Department of Bioengineering, James H. Clark Center, Stanford University, Stanford, CA 94305, USA.

5. Laboratoire International Associé CNRS-UIUC, UMR 7019, Université de Lorraine, 54506 Vandœuvre-lès-Nancy, France.

6. Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

7. Division of Cryo-EM and Bioimaging, SSRL, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA.

Abstract

A 2.7-Å cryo-EM structure and MD simulations explain water-mediated H + transport and autoinhibition of yeast V o proton channel.

Funder

National Science Foundation

National Institutes of Health

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference61 articles.

1. Recent Insights into the Structure, Regulation, and Function of the V-ATPases

2. The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function

3. The where, when, and how of organelle acidification by the yeast vacuolar H+-ATPase;Kane P. M.;Microbiol. Mol. Biol. Rev.,2006

4. The vacuolar ATPase—A nano-scale motor that drives cell biology;Harrison M. A.;Subcell. Biochem.,2018

5. Disassembly and reassembly of the yeast vacuolar H+-ATPase in vivo;Kane P. M.;J. Biol. Chem.,1995

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