Shattering barriers toward clinically meaningful MSC therapies

Author:

Levy Oren1ORCID,Kuai Rui12ORCID,Siren Erika M. J.1ORCID,Bhere Deepak23ORCID,Milton Yuka1,Nissar Nabeel3ORCID,De Biasio Michael1ORCID,Heinelt Martina1,Reeve Brock4ORCID,Abdi Reza5ORCID,Alturki Meshael67,Fallatah Mohanad7,Almalik Abdulaziz67,Alhasan Ali H.67ORCID,Shah Khalid234ORCID,Karp Jeffrey M.1248ORCID

Affiliation:

1. Center for Nanomedicine and Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Harvard-MIT Division of Health Sciences and Technology, Boston, MA, USA.

2. BWH Center of Excellence for Biomedicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.

3. Center for Stem Cell Therapeutics and Imaging, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.

4. Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.

5. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.

6. National Center of Pharmaceutical Technology, Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia.

7. KACST Center of Excellence for Biomedicine, Joint Centers of Excellence Program, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia.

8. Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Abstract

To realize the potential of MSCs, bioengineering is needed to boost potency and control heterogeneity.

Funder

National Institutes of Health

King Abdulaziz City for Science and Technology

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference177 articles.

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2. Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC

3. A study of CYP-001 for the treatment of steroid-resistant acute graft versus host disease; https://clinicaltrials.gov/ct2/show/NCT02923375.

4. Prochymal® (human adult stem cells) intravenous infusion following acute myocardial infarction (AMI); https://clinicaltrials.gov/ct2/show/NCT00877903.

5. Safety and efficacy of intravenous autologous mesenchymal stem cells for MS: A phase 2 proof of concept study (MESCAMS); https://clinicaltrials.gov/ct2/show/NCT02239393.

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