Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis

Author:

O’Neil Liam J.12ORCID,Barrera-Vargas Ana3ORCID,Sandoval-Heglund Donavon1ORCID,Merayo-Chalico Javier3ORCID,Aguirre-Aguilar Eduardo3ORCID,Aponte Angel M.4ORCID,Ruiz-Perdomo Yanira5,Gucek Marjan4ORCID,El-Gabalawy Hani2,Fox David A.6,Katz James D.5ORCID,Kaplan Mariana J.1ORCID,Carmona-Rivera Carmelo1ORCID

Affiliation:

1. Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

2. Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.

3. Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y de la Nutricion, Salvador Zubiran, Mexico City, Mexico.

4. Proteomic Core, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

5. Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

6. Division of Rheumatology and Clinical Autoimmunity Center of Excellence, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Carbamylated histone antibodies potentiate osteoclast formation and associate with bone erosion in rheumatoid arthritis.

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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