Rab7-harboring vesicles are carriers of the transferrin receptor through the biosynthetic secretory pathway

Author:

Deffieu Maika S.12ORCID,Cesonyte Ieva2ORCID,Delalande François3,Boncompain Gaelle4ORCID,Dorobantu Cristina2ORCID,Song Eli5ORCID,Lucansky Vincent2ORCID,Hirschler Aurélie3ORCID,Cianferani Sarah3ORCID,Perez Franck4ORCID,Carapito Christine3ORCID,Gaudin Raphael12ORCID

Affiliation:

1. Institut de Recherche en Infectiologie de Montpellier (IRIM) CNRS, Univ Montpellier, 34293 Montpellier, France.

2. INSERM, Univ Strasbourg, 67000 Strasbourg, France.

3. Laboratoire de Spectrométrie de Masse Bio-Organique, IPHC, UMR 7178, CNRS-Université de Strasbourg, ECPM, 67087 Strasbourg, France.

4. Institut Curie, PSL Research University, Sorbonne Université, Centre National de la Recherche Scientifique, UMR 144, 26 rue d’Ulm, F-75005 Paris, France.

5. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

Abstract

CRISPR-based bioengineering of the transferrin receptor reveals a new role for Rab7 in the biosynthetic secretory pathway.

Funder

Agence Nationale de la Recherche

National Natural Science Foundation of China

Ministry of Science and Technology of the People’s Republic of China

Fondation pour la Recherche Médicale

ATIP-Avenir

IdEx Université de Strasbourg

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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