Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR-Reference-Cited by-同舟云学术

Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR

Published:2019-03 Issue:3 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Toyama Yuki¹²^ORCID,Kontani Kenji³^ORCID,Katada Toshiaki⁴,Shimada Ichio¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

2. Japan Biological Informatics Consortium (JBiC), Aomi, Koto-ku, Tokyo 135-0064, Japan.

3. Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, Japan.

4. Molecular Cell Biology Laboratory, Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, Tokyo 202-8585, Japan.

Abstract

We demonstrate that the alternation of conformational equilibrium is a primary mechanism underlying oncogenic activities of Rac1.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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