The clonal repopulation of HSPC gene modified with anti–HIV-1 RNAi is not affected by preexisting HIV-1 infection-Reference-Cited by-同舟云学术

The clonal repopulation of HSPC gene modified with anti–HIV-1 RNAi is not affected by preexisting HIV-1 infection

Published:2020-07-24 Issue:30 Volume:6 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Suryawanshi Gajendra W.¹²^ORCID,Khamaikawin Wannisa²³^ORCID,Wen Jing¹²^ORCID,Shimizu Saki³^ORCID,Arokium Hubert¹²^ORCID,Xie Yiming¹²,Wang Eugene¹,Kim Shihyoung⁴⁵⁶,Choi Hyewon¹²⁴^ORCID,Zhang Chong⁷,Yu Hannah⁴⁵⁶^ORCID,Presson Angela P.⁷⁸^ORCID,Kim Namshin⁹^ORCID,An Dong-Sung²³,Chen Irvin S. Y.¹²¹⁰^ORCID,Kim Sanggu⁴⁵⁶^ORCID

Affiliation:

1. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

2. UCLA AIDS Institute, Los Angeles, CA 90095, USA.

3. School of Nursing, University of California, Los Angeles, CA 90095, USA.

4. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.

5. Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA.

6. Infectious Disease Institute, The Ohio State University, Columbus, OH 43210, USA.

7. Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USA.

8. Department of Biostatistics, University of California, Los Angeles, CA 90095, USA.

9. Genome Editing Research Center, Korea Research Institute of Biosciences and Biotechnology, Daejeon 34141, Republic of Korea.

10. Division of Hematology-Oncology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA.

Abstract

A novel approach enables a direct comparison of anti-HIV– and non–gene-modified stem-cell engraftment in an HIV-1–infected host.

Funder

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference60 articles.

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4. HIV Status Does Not Affect the Outcome of Autologous Stem Cell Transplantation (ASCT) for Non-Hodgkin Lymphoma (NHL)

5. High-Dose Therapy and Autologous Peripheral-Blood Stem-Cell Transplantation As Salvage Treatment for HIV-Associated Lymphoma in Patients Receiving Highly Active Antiretroviral Therapy

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