Polθ reverse transcribes RNA and promotes RNA-templated DNA repair-Reference-Cited by-同舟云学术

Polθ reverse transcribes RNA and promotes RNA-templated DNA repair

Published:2021-06-11 Issue:24 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Chandramouly Gurushankar¹^ORCID,Zhao Jiemin²^ORCID,McDevitt Shane¹^ORCID,Rusanov Timur¹^ORCID,Hoang Trung¹,Borisonnik Nikita¹,Treddinick Taylor¹^ORCID,Lopezcolorado Felicia Wednesday³^ORCID,Kent Tatiana¹^ORCID,Siddique Labiba A.¹^ORCID,Mallon Joseph¹,Huhn Jacklyn¹^ORCID,Shoda Zainab¹^ORCID,Kashkina Ekaterina¹,Brambati Alessandra⁴^ORCID,Stark Jeremy M.³,Chen Xiaojiang S.²^ORCID,Pomerantz Richard T.¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

2. Molecular and Computational Biology, USC Dornsife Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.

3. Beckman Research Institute of the City of Hope, Duarte, CA, USA.

4. Department of Cell Biology, New York University School of Medicine, New York, NY, USA.

Abstract

Polθ reverse transcribes RNA by undergoing a significant conformational change and promotes RNA-templated DNA repair.

Funder

National Institutes of Health

ASCRS Research Foundation

Argonne National Laboratory, Office of Science

Australian Psychological Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference39 articles.

1. Molecular basis of microhomology-mediated end-joining by purified full-length Polθ

2. Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

3. Low-fidelity DNA synthesis by human DNA polymerase theta

4. DNA polymerase theta specializes in incorporating synthetic expanded-size (xDNA) nucleotides;Kent T.;Nucleic Acids Res.,2016

5. Polymerase θ is a robust terminal transferase that oscillates between three different mechanisms during end-joining

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