Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence

Author:

Pärnänen Katariina M. M.1ORCID,Narciso-da-Rocha Carlos2ORCID,Kneis David3ORCID,Berendonk Thomas U.3ORCID,Cacace Damiano3ORCID,Do Thi Thuy4,Elpers Christian5,Fatta-Kassinos Despo6,Henriques Isabel7,Jaeger Thomas8,Karkman Antti1ORCID,Martinez Jose Luis9,Michael Stella G.6,Michael-Kordatou Irene6,O’Sullivan Kristin10,Rodriguez-Mozaz Sara11ORCID,Schwartz Thomas8,Sheng Hongjie1213,Sørum Henning10ORCID,Stedtfeld Robert D.13ORCID,Tiedje James M.14ORCID,Giustina Saulo Varela Della11,Walsh Fiona4,Vaz-Moreira Ivone2,Virta Marko1ORCID,Manaia Célia M.2ORCID

Affiliation:

1. Department of Microbiology, University of Helsinki, Viikinkaari 9, 00014 University of Helsinki, Finland.

2. Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina–Laboratório Associado, Escola Superior de Biotecnologia, Rua Arquiteto Lobão Vital, 172, 4200-374 Porto, Portugal.

3. Technische Universität Dresden, Institute of Hydrobiology, Dresden, Germany.

4. Department of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.

5. Aquantec GmbH, Pfinztalstraße 90, D-76227 Karlsruhe, Germany.

6. Department of Civil and Environmental Engineering and Nireas–International Water Research Centre, University of Cyprus, P.O. Box 20537, CY-1678 Nicosia, Cyprus.

7. Department of Biology and CESAM, University of Aveiro, Campus Universitário Santiago, 3810-193 Aveiro, Portugal.

8. Karlsruhe Institute of Technology (KIT)–Campus North, Institute of Functional Interfaces (IFG), P.O. Box 3640, 76021 Karlsruhe, Germany.

9. Centro Nacional de Biotecnología, CSIC, Calle Darwin 3, 20049 Madrid, Spain.

10. Norwegian University of Life Sciences, Faculty of Veterinary Medicine, Department of Food Safety and Infection Biology, Section of Microbiology, Immunology and Parasitology, Post Box 8146 Dep, 0033 Oslo, Norway.

11. Catalan Institute for Water Research (ICRA), Emili Grahit 101, 17003 Girona, Spain.

12. Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China.

13. Department of Civil and Environmental Engineering, Michigan State University, East Lansing, MI 48824, USA.

14. Center for Microbial Ecology, Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI 48824, USA.

Abstract

The antibiotic resistome in European UWTPs mirrors the gradient of north-to-south clinical antibiotic resistance prevalence.

Funder

Environmental Protection Agency

Research Promotion Foundation

Fundação para a Ciência e a Tecnologia

Suomen Akatemia

Ministerio de Economía, Industria y Competitividad, Gobierno de España

Bundesministerium für Bildung und Forschung

The Research Council of Norway

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

1. WHO Global antimicrobial resistance surveillance system (GLASS) report: Early implementation 2016–2017 (Geneva 2017); www.who.int/glass/resources/publications/early-implementation-report/en/.

2. Tackling antibiotic resistance: The environmental framework;Berendonk T. U.;Nat. Rev. Microbiol.,2015

3. Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance;Larsson D. G. J.;Environ. Int.,2018

4. WHO (World Health Organization) Global action plan on antimicrobial resistance (2015) p. 28; www.who.int/iris/handle/10665/193736.

5. ECDC (European Centre for Disease Prevention and Control) Surveillance of antimicrobial resistance in Europe 2016. Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm (2017).

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