In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease-Reference-Cited by-同舟云学术

In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease

Published:2021-10-29 Issue:44 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Meisl Georg¹^ORCID,Hidari Eric¹²^ORCID,Allinson Kieren²^ORCID,Rittman Timothy²^ORCID,DeVos Sarah L.³⁴^ORCID,Sanchez Justin S.³^ORCID,Xu Catherine K.¹^ORCID,Duff Karen E.⁵^ORCID,Johnson Keith A.³^ORCID,Rowe James B.²⁶⁷^ORCID,Hyman Bradley T.³^ORCID,Knowles Tuomas P. J.¹⁸^ORCID,Klenerman David¹⁹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.

2. Department of Clinical Neurosciences, University of Cambridge, Biomedical Campus, Cambridge CB2 0QQ, UK.

3. Department of Neurology, Harvard Medical School, MassGeneral Institute for Neuro-degenerative Disease, Massachusetts General Hospital, Charlestown, MA 02114, USA.

4. Denali Therapeutics Inc., South San Francisco, CA 94080, USA.

5. Dementia Research Institute, University College London, London W1T 7NF, UK.

6. Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 7EF, UK.

7. Cambridge University Hospitals NHS Trust, Cambridge CB2 0SZ, UK.

8. Cavendish Laboratory, University of Cambridge, 19 JJ Thomson Avenue, Cambridge CB3 0HE, UK.

9. UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0XY, UK.

Abstract

Local replication doubles the number of tau aggregate in Alzheimer’s disease only once every 5 years, limiting the overall rate.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

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