Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer-Reference-Cited by-同舟云学术

Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer

Published:2024-03-08 Issue:10 Volume:10 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Alsaiari Shahad K.¹^ORCID,Nadeef Seba¹,Daristotle John L.¹^ORCID,Rothwell William¹²^ORCID,Du Bujie¹^ORCID,Garcia Johnny¹,Zhang Linzixuan³^ORCID,Sarmadi Morteza¹^ORCID,Forster Timothy A.¹,Menon Nandita¹,Lin Stacey Qiaohui¹,Tostanoski Lisa H.⁴^ORCID,Hachmann Nicole⁴^ORCID,Wang Erika Yan¹,Ventura John D.⁴,Barouch Dan H.⁴^ORCID,Langer Robert¹³^ORCID,Jaklenec Ana¹^ORCID

Affiliation:

1. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

3. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

4. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Abstract

Nanomaterials offer unique opportunities to engineer immunomodulatory activity. In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate framework–8 (ZIF-8). The accumulation of ZIF-8 in endosomes and the pH-responsive release of its subunits enable selective engagement with endosomal Toll-like receptors, minimizing the risk of off-target activation. The intrinsic adjuvant properties of ZIF-8, along with the efficient delivery and biomimetic presentation of a severe acute respiratory syndrome coronavirus 2 spike protein receptor-binding domain trimer, primed rapid humoral and cell-mediated immunity in a dose-sparing manner. Our study offers insights for next-generation adjuvants that can potentially impact future vaccine development.

Publisher

American Association for the Advancement of Science (AAAS)

Link

https://www.science.org/doi/pdf/10.1126/sciadv.adj6380

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