Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes-Reference-Cited by-同舟云学术

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

Published:2019-08-02 Issue:8 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Elyahu Yehezqel¹²³^ORCID,Hekselman Idan³⁴,Eizenberg-Magar Inbal⁵,Berner Omer¹²³^ORCID,Strominger Itai¹²³,Schiller Maya⁶,Mittal Kritika¹²³,Nemirovsky Anna¹²³,Eremenko Ekaterina¹²³,Vital Assaf³⁴,Simonovsky Eyal³⁴^ORCID,Chalifa-Caspi Vered³^ORCID,Friedman Nir⁵^ORCID,Yeger-Lotem Esti³⁴^ORCID,Monsonego Alon¹²³^ORCID

Affiliation:

1. The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel.

2. Zlotowski Neuroscience Center and Regenerative Medicine and Stem Cell Research Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

3. National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

4. Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

5. Department of Immunology, Weizmann Institute of Science, Rehovot 7610001, Israel.

6. Departments of Immunology and Neuroscience, Rappaport Faculty of Medicine, and the Integrated Cancer Center, Technion-Israel Institute of Technology, Haifa 3525422, Israel.

Abstract

Single-cell analysis of CD4 T cells reveals a population structure associated with inflammation and declined immunity in aging.

Funder

Israel Science Foundation

Litwin and Gural Foundations

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference62 articles.

1. Successful and maladaptive T cell aging;Goronzy J. J.;Immunity,2017

2. Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories