Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity-Reference-Cited by-同舟云学术

Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity

Published:2021-01 Issue:1 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Cheng Kuoyuan¹²^ORCID,Nair Nishanth Ulhas¹^ORCID,Lee Joo Sang¹³^ORCID,Ruppin Eytan¹²^ORCID

Affiliation:

1. Cancer Data Science Laboratory (CDSL), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.

2. Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD, USA.

3. Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea.

Abstract

Expression pattern of synthetic lethality genes is a previously unknown factor associated with cancer risk across human tissues.

Funder

Intramural Research Program of the National Institutes of Health (NIH), National Cancer Institute and the Center for Cancer Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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