On-demand biomanufacturing of protective conjugate vaccines

Author:

Stark Jessica C.123ORCID,Jaroentomeechai Thapakorn4ORCID,Moeller Tyler D.4ORCID,Hershewe Jasmine M.123ORCID,Warfel Katherine F.123ORCID,Moricz Bridget S.5,Martini Anthony M.5ORCID,Dubner Rachel S.6ORCID,Hsu Karen J.7,Stevenson Taylor C.8,Jones Bradley D.59ORCID,DeLisa Matthew P.48ORCID,Jewett Michael C.1231011ORCID

Affiliation:

1. Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Rd Technological Institute E136, Evanston, IL 60208-3120, USA.

2. Center for Synthetic Biology, Northwestern University, 2145 Sheridan Rd Technological Institute E136, Evanston, IL 60208-3120, USA.

3. Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, IL 60208-3120, USA.

4. Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, 120 Olin Hall, Ithaca, NY 14853, USA.

5. Department of Microbiology and Immunology, University of Iowa, 51 Newton Rd 3-403 Bowen Science Building, Iowa City, IA 52242, USA.

6. Department of Biological Sciences, Northwestern University, 2205 Tech Drive Hogan Hall 2144, Evanston, IL 60208-3500, USA.

7. Department of Mechanical Engineering, Northwestern University, 2145 Sheridan Rd Technological Institute B224, Evanston, IL 60208-3120, USA.

8. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Weill Hall, Ithaca, NY 14853, USA.

9. Graduate Program in Genetics, 431 Newton Rd, University of Iowa, Iowa City, IA 52242, USA.

10. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, 676 N. St Clair St, Suite 1200, Chicago, IL 60611-3068, USA.

11. Simpson-Querrey Institute, Northwestern University, 303 E. Superior St, Suite 11-131 Chicago, IL 60611-2875, USA.

Abstract

In vitro conjugate vaccine expression technology enables rapid and portable biosynthesis of protective antibacterial vaccines.

Funder

National Science Foundation

David and Lucile Packard Foundation

Defense Threat Reduction Agency

Camille and Henry Dreyfus Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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