Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β 40 (Aβ 40 ) by the peptide fragment Aβ 16

Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β 40 (Aβ 40 ) by the peptide fragment Aβ 16–22

Published:2019-06-07 Issue:6 Volume:5 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

Bunce Samuel J.¹²^ORCID,Wang Yiming³^ORCID,Stewart Katie L.²⁴,Ashcroft Alison E.²⁴,Radford Sheena E.²⁴^ORCID,Hall Carol K.³^ORCID,Wilson Andrew J.¹²^ORCID

Affiliation:

1. School of Chemistry, University of Leeds, Leeds LS2 9JT, UK.

2. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK.

3. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-7905, USA.

4. School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

Abstract

Combined experiment and simulation reveals a structural mechanism of surface-catalyzed nucleation in Aβ amyloid formation.

Funder

NIH Office of the Director

NSF Office of the Director

Wellcome Trust

Engineering and Physical Sciences Research Council

European Research Council

Biotechnology and Biological Sciences Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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